ORAL S2-AG85 DNA VACCINE ACTIVATED INTESTINAL CELL DSDNA AND RNA SENSORS TO PROMOTE THE PRESENTATION OF INTESTINAL ANTIGEN

Oral S2-Ag85 DNA Vaccine Activated Intestinal Cell dsDNA and RNA Sensors to Promote the Presentation of Intestinal Antigen

Objective.To explore the molecular mechanism by which Star Dish oral S2-Ag85DNA vaccines present intestinal antigens.The oral S2-Ag85 vaccine has been shown to protect the human body and effectively improve the titration of the vaccine by acting on intestinal mucosa cells and enhancing their immunogenicity.Method.Mice were immunized with the recomb

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A study of The Frequency and Type of Mutation in Exon 11 in BRCA1 and BRCA2 Genes In Breast Cancer Women With Positive Family History

Background:Both BRCA1 and BRCA2 are tumor suppressor gene and are inherited as an autosomal dominant.The cumulative lifetime risk of developing invasive breast cancer for those with BRCA1 or BRCA2 mutations ranges from 53% to 89%.Familial breast cancer represent less than 10% of all cancers of the breast, and cancers related to BRCA1 and BRCA2 fami

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Single-cell transcriptomics of popliteal lymphatic vessels and peripheral veins reveals altered lymphatic muscle and immune cell populations in the TNF-Tg arthritis model

Abstract Background Lymphatic dysfunction exists in tumor necrosis factor transgenic (TNF-Tg) mice and rheumatoid arthritis (RA) patients.While joint-draining TNF-Tg popliteal lymphatic vessels (PLVs) have deficits in contractility during end-stage arthritis, the nature of lymphatic muscle cells (LMCs) and their TNF-altered transcriptome remain unk

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